Direct Differential Photometric Stereo Shape Recovery of Diffuse and Specular Surfaces

This is the author accepted manuscript. The final version is available from Springer via http://dx.doi.org/10.1007/s10851-016-0633-0Recovering the 3D shape of an object from shading is a challenging problem due to the complexity of modeling light propagation and surface reflections. Photometric Stereo (PS) is broadly considered a suitable approach for high-resolution shape recovery, but its functionality is restricted to a limited set of object surfaces and controlled lighting setup. In particular, PS models generally consider reflection from objects as purely diffuse, with specularities being regarded as a nuisance that breaks down shape reconstruction. This is a serious drawback for implementing PS approaches, since most common materials have prominent specular components. In this paper, we propose a PS model that solves the problem for both diffuse and specular components aimed at shape recovery of generic objects with the approach being independent of the albedo values thanks to the image ratio formulation used. Notably, we show that by including specularities, it is possible to solve the PS problem for a minimal number of three images using a setup with three calibrated lights and a standard industrial camera. Even if an initial separation of diffuse and specular components is still required for each input image, experimental results on synthetic and real objects demonstrate the feasibility of our approach for shape reconstruction of complex geometries.The first author acknowledges the support of INDAM under the GNCS research Project “Metodi numerici per la regolarizzazione nella ricostruzione feature-preserving di dati.

A comparative analysis of denoising algorithms for extragalactic imaging surveys

Aims. We present a comprehensive analysis of the performance of noise-reduction (denoising) algorithms to determine whether they provide advantages in source detection, mitigating noise on extragalactic survey images. Methods. The methods we analyze here are representative of different algorithmic families: Perona-Malik filtering, bilateral filter, total variation denoising, structure-texture image decomposition, non-local means, wavelets, and block-matching We tested the algorithms on simulated images of extragalactic fields with resolution and depth typical of the Hubble, Spitzer, and Euclid Space Telescopes, and of ground-based instruments. After choosing their best internal parameters configuration, we assessed their performance as a function of resolution, background level, and image type, in addition to testing their ability to preserve the objects fluxes and shapes. Finally, we analyze, in terms of completeness and purity, the catalogs that were extracted after applying denoising algorithms on a simulated Euclid Wide Survey VIS image and on real H160 and K-band (HAWK-I) observations of the CANDELS GOODS-South field. Results. Denoising algorithms often outperform the standard approach of filtering with the point spread function (PSF) of the image. Applying structure-texture image decomposition, Perona-Malik filtering, the total variation method by Chambolle, and bilateral filtering on the Euclid-VIS image, we obtain catalogs that are both more pure and complete by 0.2 magnitude than those based on the standard approach. The same result is achieved with the structure-texture image decomposition algorithm applied on the H160 image. The relative advantage of denoising techniques with respect to PSF filtering rises with increasing depth. Moreover, these techniques better preserve the shape of the detected objects with respect to PSF smoothing. Conclusions. Denoising algorithms provide significant improvements in the detection of faint objects and enhance the scientific return of current and future extragalactic surveys. We identify the most promising denoising algorithms among the 20 techniques considered in this study

A comparative analysis of denoising algorithms for extragalactic imaging surveys

We present a comprehensive analysis of the performance of noise-reduction (``denoising'') algorithms to determine whether they provide advantages in source detection on extragalactic survey images. The methods under analysis are Perona-Malik filtering, Bilateral filter, Total Variation denoising, Structure-texture image decomposition, Non-local means, Wavelets, and Block-matching. We tested the algorithms on simulated images of extragalactic fields with resolution and depth typical of the Hubble, Spitzer, and Euclid Space Telescopes, and of ground-based instruments. After choosing their best internal parameters configuration, we assess their performance as a function of resolution, background level, and image type, also testing their ability to preserve the objects fluxes and shapes. We analyze in terms of completeness and purity the catalogs extracted after applying denoising algorithms on a simulated Euclid Wide Survey VIS image, on real H160 (HST) and K-band (HAWK-I) observations of the CANDELS GOODS-South field. Denoising algorithms often outperform the standard approach of filtering with the Point Spread Function (PSF) of the image. Applying Structure-Texture image decomposition, Perona-Malik filtering, the Total Variation method by Chambolle, and Bilateral filtering on the Euclid-VIS image, we obtain catalogs that are both more pure and complete by 0.2 magnitudes than those based on the standard approach. The same result is achieved with the Structure-Texture image decomposition algorithm applied on the H160 image. The advantage of denoising techniques with respect to PSF filtering increases at increasing depth. Moreover, these techniques better preserve the shape of the detected objects with respect to PSF smoothing. Denoising algorithms provide significant improvements in the detection of faint objects and enhance the scientific return of current and future extragalactic surveys.Comment: 30 pages, 55 figures; accepted for publication in A&

Brain Plasticity in Charcot-Marie-Tooth Type 1A Patients? A Combined Structural and Diffusion MRI Study

Central nervous system involvement has been described in peripheral neuropathies, including different forms of Charcot-Marie-Tooth (CMT) disease. The aim of our study was to systematically investigate possible brain structural modifications in CMT1A patients, using volumetric MRI, and diffusion tensor imaging (DTI). In this prospective cross-sectional study, from May 2017 to May 2019, we acquired 3T MRI brain scans of genetically confirmed CMT1A patients and age- and sex-comparable healthy controls. Patients also underwent clinical and electrophysiological examinations assessing motor and sensory domains. Voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) analyses were performed using a non-parametric approach based on permutations, including age and sex (and total intracranial volume for VBM) as nuisance covariates. When between-group differences emerged at VBM or TBSS analyses, the first eigenvariate was extracted from the cluster and its age- and sex-adjusted standardized residuals tested for correlation with clinical and electrophysiological variables. Twenty CMT1A patients (34.5 ± 11.1 years; M/F:11/9) were enrolled, along with 20 healthy controls (30.1 ± 10.2 years; M/F:11/9). The VBM analysis revealed clusters of significantly increased GM volume in CMT1A patients compared to healthy controls, encompassing the bilateral cerebellar lobules III-VI and the left hippocampus (all ps = 0.04), with no differences in terms of DTI metrics at the TBSS analysis. A negative correlation (r = −0.502, p = 0.03) emerged between ulnar compound motor action potential and the z-scores corresponding to the right cerebellar cluster of augmented GM volume. Our data show evidence of structural reorganization in the brain of CMT1A patients, possibly reflecting neural plasticity mechanisms in response to peripheral nerve pathology and modulating the effect of axonal degeneration on functional impairment

On the well-posedness of uncalibrated photometric stereo under general lighting

Uncalibrated photometric stereo aims at estimating the 3D-shape of a surface, given a set of images captured from the same viewing angle, but under unknown, varying illumination. While the theoretical foundations of this inverse problem under directional lighting are well-established, there is a lack of mathematical evidence for the uniqueness of a solution under general lighting. On the other hand, stable and accurate heuristical solutions of uncalibrated photometric stereo under such general lighting have recently been proposed. The quality of the results demonstrated therein tends to indicate that the problem may actually be well-posed, but this still has to be established. The present paper addresses this theoretical issue, considering first-order spherical harmonics approximation of general lighting. Two important theoretical results are established. First, the orthographic integrability constraint ensures uniqueness of a solution up to a global concave-convex ambiguity , which had already been conjectured, yet not proven. Second, the perspective integrability constraint makes the problem well-posed, which generalizes a previous result limited to directional lighting. Eventually, a closed-form expression for the unique least-squares solution of the problem under perspective projection is provided , allowing numerical simulations on synthetic data to empirically validate our findings

Clinical criteria and diagnostic assessment of fibromyalgia: position statement of the Italian Society of Neurology-Neuropathic Pain Study Group

Background: The role of central and/or peripheral nervous system dysfunction is basically fundamental in fibromyalgia. Aim: The aim of this position statement on behalf of the Neuropathic Pain Study Group of the Italian Society of Neurology is to give practical guidelines for the clinical and instrumental assessment of fibromyalgia (FM) in the neurological clinical practice, taking into consideration recent studies. Methods: Criteria for study selection and consideration were original studies, case-controls design, use of standardized methodologies for clinical practice, and FM diagnosis with ACR criteria (2010, 2011, 2016). Results: ACR criteria were revised. For diagnostic procedure of small-fiber pathology, 47 studies were totally considered. Recent diagnostic criteria should be applied (ACR, 2016). A rheumatologic visit seems mandatory. The involvement of small fibers should request at least 2 among HRV + SSR and/or laser-evoked responses and/or skin biopsy and/or corneal confocal microscopy, eventually followed by monitoring of metabolic and/or immunological/ and or/paraneoplastic basis, to be repeated at 1-year follow-up. Conclusions: The correct diagnostic approach to FM could promote the exclusion of the known causes of small-fiber impairment. The research toward common genetic factors would be useful to promote a more specific therapeutic approach

Recommendations for pre-symptomatic genetic testing for hereditary transthyretin amyloidosis in the era of effective therapy: a multicenter Italian consensus

Hereditary transthyretin amyloidosis (ATTRv, v for variant) is a late-onset, autosomal dominant disease caused by progressive extracellular deposition of transthyretin amyloid fibrils, leading to organ damage and death. For other late-onset fatal diseases, as Huntington's disease, protocols for pre-symptomatic genetic testing (PST) are available since decades. For ATTRv, limited experience has been reported to date, mostly gathered before the availability of approved therapies. We aimed at developing recommendations for a safe and feasible PST protocol in ATTRv in the era of emerging treatments, taking also into account Italian patients' characteristics and healthcare system rules. After an initial survey on ongoing approaches to PST for ATTRv in Italy, two roundtable meetings were attended by 24 experts from 16 Italian centers involved in the diagnosis and care of this disease. Minimal requirements for PST offer and potential critical issues were highlighted. By November 2019, 457 families affected by ATTRv with 209 molecularly confirmed pre-symptomatic carriers were counted. The median age at PST was 41.3years of age, regardless of the specific mutation. Half of the Italian centers had a multidisciplinary team, including a neurologist, an internist, a cardiologist, a medical geneticist and a psychologist, although in most cases not all the specialists were available in the same center. A variable number of visits was performed at each site. Experts agreed that PST should be offered only in the context of genetic counselling to at risk individuals aged 18 or older. Advertised commercial options for DNA testing should be avoided. The protocol should consist of several steps, including a preliminary clinical examination, a pre-test information session, an interval time, the genetic test and a post-test session with the disclosure of the test results, in the context of an experienced multidisciplinary team. Recommendations for best timing were also defined. Protocols for PST in the context of ATTRv can be refined to offer at risk individuals the best chance for early diagnosis and timely treatment start, while respecting autonomous decisions and promoting safe psychological adjustment to the genetic result

Clinical spectrum and frequency of Charcot–Marie–Tooth disease in Italy: Data from the National CMT Registry

Background and purpose: Data are reported from the Italian CMT Registry.Methods: The Italian CMT Registry is a dual registry where the patient registers and chooses a reference center where the attending clinician collects a minimal dataset of information and administers the Charcot-Marie-Tooth (CMT) Examination/Neuropathy Score. Entered data are encrypted.Results: Overall, 1012 patients had registered (535 females) and 711 had received a genetic diagnosis. Demyelinating CMT (65.3%) was more common than axonal CMT2 (24.6%) and intermediate CMT (9.0%). The PMP22 duplication was the most frequent mutation (45.2%), followed by variants in GJB1 and MPZ (both similar to 10%) and MFN2 (3.3%) genes. A relatively high mutation rate in some "rare" genes (HSPB1 1.6%, NEFL 1.5%, SH3TC2 1.5%) and the presence of multiple mutation clusters across Italy was observed. CMT4A was the most disabling type, followed by CMT4C and CMT1E. Disease progression rate differed depending on the CMT subtype. Foot deformities and walking difficulties were the main features. Shoe inserts and orthotic aids were used by almost one-half of all patients. Scoliosis was present in 20% of patients, especially in CMT4C. Recessive forms had more frequently walking delay, walking support need and wheelchair use. Hip dysplasia occurred in early-onset CMT.Conclusions: The Italian CMT Registry has proven to be a powerful data source to collect information about epidemiology and genetic distribution, clinical features and disease progression of CMT in Italy and is a useful tool for recruiting patients in forthcoming clinical trials

Cerebellar ataxia, neuropathy, vestibular areflexia syndrome due to RFC1 repeat expansion

Ataxia, causing imbalance, dizziness and falls, is a leading cause of neurological disability. We have recently identified a biallelic intronic AAGGG repeat expansion in replication factor complex subunit 1 (RFC1) as the cause of cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) and a major cause of late onset ataxia. Here we describe the full spectrum of the disease phenotype in our first 100 genetically confirmed carriers of biallelic repeat expansions in RFC1 and identify the sensory neuropathy as a common feature in all cases to date. All patients were Caucasian and half were sporadic. Patients typically reported progressive unsteadiness starting in the sixth decade. A dry spasmodic cough was also frequently associated and often preceded by decades the onset of walking difficulty. Sensory symptoms, oscillopsia, dysautonomia and dysarthria were also variably associated. The disease seems to follow a pattern of spatial progression from the early involvement of sensory neurons, to the later appearance of vestibular and cerebellar dysfunction. Half of the patients needed walking aids after 10 years of disease duration and a quarter were wheelchair dependent after 15 years. Overall, two-thirds of cases had full CANVAS. Sensory neuropathy was the only manifestation in 15 patients. Sixteen patients additionally showed cerebellar involvement, and six showed vestibular involvement. The disease is very likely to be underdiagnosed. Repeat expansion in RFC1 should be considered in all cases of sensory ataxic neuropathy, particularly, but not only, if cerebellar dysfunction, vestibular involvement and cough coexist